Description

16-Methylpregna-1,4-Diene-17,21-Diol-3,20-Dione is a high-purity steroid derivative with significant utility in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate for the production of novel therapeutic agents, particularly in the fields of endocrinology and anti-inflammatory drug discovery. It is primarily sought by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in the synthesis of complex steroid-based molecules.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent glucocorticoids and other specialized steroid-based active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry programs to explore new drug candidates targeting hormone receptors and inflammatory pathways.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial manufacturing of steroid drugs.
• Biochemical Studies: Utilized in vitro to study steroid metabolism, enzyme inhibition, and receptor binding affinities.

Basic Information

Product Name	16-Methylpregna-1,4-Diene-17,21-Diol-3,20-Dione
CAS No.	19784-87-3
Molecular Formula	C22H28O4
Molecular Weight	356.46 g/mol
Synonyms	16-Methylpregna-1,4-diene-17,21-diol-3,20-dione; 16-Methylprednisolone; 16-Methyl-1,4-pregnadiene-17,21-diol-3,20-dione; 16-Methyl-δ1-pregnadiene-17,21-diol-3,20-dione; 16-Methyl-1-dehydro-17,21-dihydroxypregn-4-ene-3,20-dione; 16-Methylprednisolone (Intermediate)
EINECS	Contact for details

Quality Control

Our 16-Methylpregna-1,4-Diene-17,21-Diol-3,20-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your internal specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.