Description

2'-O,3'-o-(Phenylboranediyl)Uridine is a chemically modified nucleoside derivative, where a phenylborane group bridges the 2' and 3' hydroxyl positions of the ribose sugar. This compound is a critical intermediate and building block in the synthesis of complex oligonucleotides and nucleotide analogs. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery, antisense therapy development, and advanced nucleic acid research.

Application

• Oligonucleotide Synthesis: A key protected intermediate for the solid-phase synthesis of RNA and modified RNA strands.
• Antisense & siRNA Therapeutics: Used in the research and development of gene-silencing drugs and therapeutic oligonucleotides.
• Prodrug Development: Serves as a precursor for nucleotide prodrugs, particularly in antiviral and anticancer research.
• Chemical Biology Probes: Enables the creation of labeled or modified nucleosides for studying biological processes and enzyme mechanisms.
• Pharmaceutical Intermediates: An essential building block for manufacturing active pharmaceutical ingredients (APIs) in nucleotide-based therapies.
• Bioconjugation: The boranediyl group can be leveraged for further chemical modifications and conjugation strategies.

Basic Information

Product Name	2'-O,3'-o-(Phenylboranediyl)Uridine
CAS No.	19455-04-0
Molecular Formula	C15H15BN2O6
Molecular Weight	330.11 g/mol
Synonyms	2',3'-O-(Phenylboranediyl)uridine; Uridine, 2',3'-O-(phenylboranediyl)-; 2'-O,3'-O-[(1R)-1-Phenyl-1,3-propanediyl]uridine; Phenylboronic acid 2',3'-acetal with uridine; 2',3'-O-(Phenylboronate) uridine; RNA building block intermediate; Protected uridine derivative; Nucleoside boronate ester
EINECS	Contact for details

Quality Control

Our 2'-O,3'-o-(Phenylboranediyl)Uridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. We provide Certificates of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere or anhydrous conditions to maintain stability. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.