Description

o-Tolyl Chloroformate is a versatile and highly reactive organic intermediate used in the synthesis of various valuable compounds. Its primary value lies in its role as a key building block for introducing the o-tolyloxycarbonyl protecting group and for constructing carbamate and carbonate derivatives. This compound is essential for manufacturers and R&D teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of active pharmaceutical ingredients (APIs), particularly in constructing carbamate-based prodrugs and protecting amine functionalities during complex multi-step syntheses.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where the o-tolyl moiety imparts specific biological activity and stability.
• Polymer Chemistry: Serves as a monomer or modifying agent in the production of specialty polycarbonates and polyurethanes, enhancing material properties.
• Peptide Chemistry: Employed as a coupling reagent or for introducing protecting groups in solid-phase peptide synthesis (SPPS).
• Chemical Research & Development: A valuable reagent in organic synthesis laboratories for creating novel carbonates, urethanes, and other functional molecules.
• Dye and Pigment Manufacturing: Acts as an intermediate in the synthesis of specialized dyes and colorants.

Basic Information

Product Name	o-Tolyl Chloroformate
CAS No.	19358-42-0
Molecular Formula	C8H7ClO2
Molecular Weight	170.59 g/mol
Synonyms	2-Methylphenyl Chloroformate; o-Cresyl Chloroformate; 2-Tolyl Chloroformate; Chloroformic Acid o-Tolyl Ester; (2-Methylphenyl) Carbonochloridate; o-Toluyl Chloroformate; 2-Methylphenyl Carbonochloridate
EINECS	Contact for details

Quality Control

Our o-Tolyl Chloroformate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the rigorous standards required by our global customer base in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
o-Cresol Content	≤ 1.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.