Description

2'-Deoxy-5-Methylisocytidine is a modified nucleoside analog of significant interest in advanced pharmaceutical and biochemical research. This compound serves as a critical building block for the synthesis of oligonucleotides, enabling the development of novel therapeutics and diagnostic tools. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antisense oligonucleotides, siRNA, and other nucleic acid-based technologies. The product is supplied with a high level of purity to meet the stringent requirements of these applications.

Application

• Antisense Oligonucleotide Synthesis: A key phosphoramidite monomer for constructing oligonucleotides designed to modulate gene expression.
• siRNA and miRNA Research: Used in the preparation of chemically modified small interfering RNA (siRNA) and microRNA (miRNA) to enhance stability and specificity.
• Therapeutic Nucleic Acid Development: Serves as a crucial intermediate in the R&D pipeline for novel drugs targeting genetic diseases, cancers, and viral infections.
• Diagnostic Probe Fabrication: Incorporated into nucleic acid probes for advanced diagnostic assays and detection systems.
• Biochemical Research: Employed in studies investigating DNA/RNA structure, function, and enzyme interactions.
• Building Block for Nucleoside Analogs: Used as a precursor for the synthesis of more complex nucleoside derivatives with potential biological activity.

Basic Information

Product Name	2'-Deoxy-5-Methylisocytidine
CAS No.	19316-88-2
Molecular Formula	C10H15N3O4
Molecular Weight	241.25 g/mol
Synonyms	5-Methyl-2'-deoxyisocytidine; 5-Methyldeoxyisocytidine; d5miC; 1-(2-Deoxy-β-D-ribofuranosyl)-5-methyl-2(1H)-pyrimidinone; 2'-Deoxy-5-methylisocytidine; 5-Methyl-2'-deoxycytidine isomer; 5-Methyldeoxycytidine (isomer); 5-Methyl-dC (isomer)
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-5-Methylisocytidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP starting material requirements. Specifications are designed to meet the high standards of the pharmaceutical and biotechnology industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or with desiccant after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.