Description

2,3,5,6-Pentafluoro-α-(Nitromethyl)Benzyl Alcohol is a highly fluorinated aromatic building block that combines a benzyl alcohol moiety with a nitromethyl group. This unique structure makes it a valuable intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where the introduction of fluorine atoms is critical for modulating properties like metabolic stability, lipophilicity, and bioavailability. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with enhanced performance characteristics.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in areas like oncology, CNS disorders, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced, high-performance pesticides and herbicides where fluorine substitution improves efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a precursor for fluorinated components in liquid crystal displays (LCDs), enhancing dielectric anisotropy and stability.
• Polymer Modification: Incorporated as a monomer or modifier to create specialty fluoropolymers with unique surface, thermal, and chemical resistance properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, nucleophilic substitutions, and reduction reactions to introduce complex, multi-fluorinated aromatic segments.
• Material Science Research: Employed in developing novel organic electronic materials, such as semiconductors for OLEDs or OFETs.

Basic Information

Product Name	2,3,5,6-Pentafluoro-α-(Nitromethyl)Benzyl Alcohol
CAS No.	19282-52-1
Molecular Formula	C8H4F5NO3
Molecular Weight	257.12 g/mol
Synonyms	α-(Nitromethyl)-2,3,5,6-pentafluorobenzyl Alcohol; (2,3,5,6-Tetrafluoro-4-nitromethylphenyl)methanol; 2,3,5,6-Pentafluoro-α-(nitromethyl)benzenemethanol; Pentafluoronitromethylbenzyl Alcohol; Benzyl alcohol, α-(nitromethyl)-2,3,5,6-pentafluoro-; 1-(2,3,5,6-Tetrafluoro-4-(hydroxymethyl)phenyl)nitromethane
EINECS	Contact for details

Quality Control

Every batch of 2,3,5,6-Pentafluoro-α-(Nitromethyl)Benzyl Alcohol is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.