Description

2',3'-Isopropylidene Adenosine-5'-Carboxylic Acid is a key protected nucleoside derivative, serving as a crucial synthetic intermediate in advanced organic chemistry. Its primary value lies in enabling the precise construction of modified nucleotides and oligonucleotides, where protecting group chemistry is essential. This compound is particularly vital for researchers and manufacturers in the pharmaceutical and biotechnology sectors engaged in the development of novel therapeutics, diagnostic probes, and biochemical tools.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel adenosine receptor agonists/antagonists and other nucleoside-based drug candidates.
• Oligonucleotide Synthesis: Used in the preparation of modified oligonucleotides for antisense therapy, siRNA, and aptamer development.
• Biochemical Research: Serves as a precursor for labeled nucleotides (e.g., fluorescent or radioactive) used in molecular biology assays and diagnostics.
• Prodrug Development: Utilized in creating prodrug forms of nucleoside analogs to improve bioavailability and targeting.
• Enzyme Substrate Studies: Acts as a substrate or inhibitor in studies of kinases, polymerases, and other nucleotide-processing enzymes.
• Material Science: Potential monomer for creating novel biomimetic polymers and functionalized surfaces.

Basic Information

Product Name	2',3'-Isopropylidene Adenosine-5'-Carboxylic Acid
CAS No.	19234-66-3
Molecular Formula	C14H17N5O6
Molecular Weight	351.32 g/mol
Synonyms	Adenosine-5'-carboxylic acid, 2',3'-O-(1-methylethylidene)-; 2',3'-O-Isopropylideneadenosine-5'-carboxylic Acid; 5'-Carboxy-2',3'-O-isopropylideneadenosine; 2',3'-O-(1-Methylethylidene)adenosine-5'-carboxylic Acid; 2',3'-Isopropylideneadenosine-5'-carboxylic Acid; N6-Adenosine-5'-carboxylic acid, 2',3'-O-(1-methylethylidene)-; Protected Adenosine-5'-Carboxylic Acid
EINECS	Contact for details

Quality Control

Our 2',3'-Isopropylidene Adenosine-5'-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurities is provided with every shipment to ensure it meets the exacting standards required for research and pharmaceutical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.