Description

Thymidine-3',5'-Dinitrate is a chemically modified nucleoside derivative where nitrate ester groups are introduced at the 3' and 5' positions of the thymidine sugar moiety. This compound is of significant interest in biochemical and pharmaceutical research, particularly as a precursor or model compound for studying nucleotide metabolism and nitric oxide (NO)-releasing prodrugs. It serves as a critical intermediate for researchers and manufacturers in advanced life science applications. Key industries that utilize this specialty chemical include pharmaceutical R&D, academic research institutions, and biotechnology companies focusing on nucleotide-based therapeutics.

Application

• Pharmaceutical Research: Used as a key intermediate in the synthesis of novel nucleoside-based prodrugs designed for targeted nitric oxide release.
• Biochemical Studies: Serves as a model compound to investigate the metabolism, stability, and biological activity of nitrated nucleosides.
• Precursor for Analogue Synthesis: Acts as a building block for creating a library of structurally related compounds for structure-activity relationship (SAR) studies.
• Vasodilation Research: Employed in cardiovascular research to study the effects of nucleotide-derived NO donors on vascular tissues.
• Reference Standard: Utilized as an analytical standard in HPLC, LC-MS, or NMR for quality control and method development in laboratory settings.

Basic Information

Product Name	Thymidine-3',5'-Dinitrate
CAS No.	19204-90-1
Molecular Formula	C10H13N3O8
Molecular Weight	303.23 g/mol
Synonyms	3',5'-Dinitrothymidine; Thymidine 3',5'-dinitrate; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione 3',5'-dinitrate; 5-Methyl-2'-deoxyuridine 3',5'-dinitrate; Nitrothymidine; dT Nitrate Ester
EINECS	Contact for details

Quality Control

Our Thymidine-3',5'-Dinitrate is produced and handled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods (NMR, IR) for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.