Description

3β-(Trimethylsilyloxy)Pregn-5-En-20-One is a high-purity steroidal intermediate, specifically a silyl-protected derivative of pregnenolone. This compound is critical for synthetic pathways requiring selective protection of the 3β-hydroxy group, enabling further chemical modifications at other positions on the steroid nucleus. It is an essential building block for researchers and manufacturers in the pharmaceutical and fine chemical industries developing novel steroid-based therapeutics and advanced chemical entities.

Application

• Pharmaceutical Intermediate: Key precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) based on steroid scaffolds, including hormones and anti-inflammatory agents.
• Research & Development: Used in organic and medicinal chemistry research for studying steroid metabolism, receptor binding, and developing new synthetic methodologies.
• Fine Chemical Synthesis: Serves as a protected starting material for the production of custom steroidal compounds and high-value specialty chemicals.
• Reference Standard: Can be utilized as an analytical standard in quality control laboratories for method development and impurity profiling of related steroid products.

Basic Information

Product Name	3β-(Trimethylsilyloxy)Pregn-5-En-20-One
CAS No.	18919-58-9
Molecular Formula	C25H42O2Si
Molecular Weight	402.69 g/mol
Synonyms	Pregnenolone 3β-trimethylsilyl ether; 3β-Trimethylsiloxypregn-5-en-20-one; 20-Oxo-5-pregnen-3β-yl trimethylsilyl ether; 3β-Hydroxypregn-5-en-20-one trimethylsilyl ether; Pregn-5-en-3β-ol-20-one, 3-(trimethylsilyl) ether; NSC 163044; Pregnenolone TMS ether
EINECS	Contact for details

Quality Control

Our 3β-(Trimethylsilyloxy)Pregn-5-En-20-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.