Description

3,16α,17β-Tris(Trimethylsiloxy)-1,3,5(10)-Estratriene is a high-purity, steroidal intermediate featuring trimethylsilyl (TMS) protecting groups. This compound is critical for advanced pharmaceutical synthesis, offering a protected and reactive scaffold for the development of novel steroid-based therapeutics. It is primarily utilized by research institutions and pharmaceutical manufacturers specializing in hormone research, drug discovery, and the production of complex active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of steroidal drugs and hormone analogs.
• Research & Development: Used in academic and industrial laboratories for investigating new synthetic pathways and biological activities of modified steroids.
• API Synthesis: Serves as a protected precursor in the commercial-scale manufacturing of complex active pharmaceutical ingredients.
• Hormone Analog Development: Facilitates the creation of novel estrogen receptor modulators and other therapeutic steroid derivatives.
• Process Chemistry: Employed in process optimization and scale-up studies for more efficient steroid production.

Basic Information

Product Name	3,16α,17β-Tris(Trimethylsiloxy)-1,3,5(10)-Estratriene
CAS No.	18888-17-0
Molecular Formula	C30H52O3Si3
Molecular Weight	545.0 g/mol
Synonyms	Estratriene, 3,16α,17β-tris(trimethylsiloxy)-; 1,3,5(10)-Estratriene-3,16α,17β-triol, tris(trimethylsilyl) ether; Tris(trimethylsilyl) ether of Estriol; Estriol tris(trimethylsilyl) ether; 3,16α,17β-Tris-O-(trimethylsilyl)estriol; TMS-Estriol; Estriol TMS derivative; 18888-17-0
EINECS	Contact for details

Quality Control

Our 3,16α,17β-Tris(Trimethylsiloxy)-1,3,5(10)-Estratriene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.