Description

3-Methoxy-17β-(Trimethylsiloxy)-1,3,5(10)-Estratriene is a key steroidal intermediate featuring a trimethylsilyl-protected hydroxyl group. This compound is of significant value in pharmaceutical synthesis, particularly for the production of high-purity steroid hormones and active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical industries for advanced organic synthesis and process development.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of steroidal drugs and hormones.
• Steroid Hormone Research: Used in academic and industrial R&D for developing novel estrogen analogs and receptor modulators.
• Process Chemistry: Serves as a protected intermediate in scalable API manufacturing processes, enabling specific chemical transformations.
• Fine Chemical Synthesis: Employed in the preparation of complex, high-value specialty chemicals for various life science applications.
• Reference Standard: Can be utilized as a chromatographic or spectroscopic standard for quality control and analytical method development.

Basic Information

Product Name	3-Methoxy-17β-(Trimethylsiloxy)-1,3,5(10)-Estratriene
CAS No.	18880-67-6
Molecular Formula	C22H34O2Si
Molecular Weight	358.60 g/mol
Synonyms	17β-(Trimethylsiloxy)-3-methoxyestra-1,3,5(10)-triene; 3-Methoxyestra-1,3,5(10)-trien-17β-ol trimethylsilyl ether; Estra-1,3,5(10)-trien-17β-ol, 3-methoxy-, trimethylsilyl ether; 3-Methoxy-17β-trimethylsiloxyestra-1,3,5(10)-triene; 3-Methoxyestratriene 17β-trimethylsilyl ether; TMS-Ether of 3-Methoxyestradiol; 18880-67-6 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 3-Methoxy-17β-(Trimethylsiloxy)-1,3,5(10)-Estratriene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.