Description

5-Fluorouridine is a fluorinated nucleoside analog that serves as a critical building block in medicinal chemistry and biochemical research. Its primary value lies in its role as a precursor for synthesizing more complex fluorinated compounds, including potential antiviral and anticancer agents. This high-purity intermediate is essential for pharmaceutical R&D, academic research, and the production of specialty fine chemicals targeting nucleoside-based therapies.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated nucleoside analogs with potential antiviral (e.g., anti-hepatitis, anti-herpes) and anticancer activity.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate RNA metabolism, thymidylate synthase inhibition, and nucleoside transport mechanisms.
• Antisense & Oligonucleotide Synthesis: Incorporated into oligonucleotide chains to modify their stability, hybridization properties, and biological activity for therapeutic and diagnostic applications.
• Pro-drug Development: Serves as a starting material for developing novel pro-drugs designed to improve the bioavailability and targeting of fluoropyrimidine agents.
• Reference Standard: Utilized as a high-purity analytical standard in quality control (QC) and research laboratories for method development and validation.
• Chemical Biology Probes: Employed in the creation of molecular probes to study cellular processes involving RNA incorporation and metabolism.

Basic Information

Product Name	5-Fluorouridine
CAS No.	18814-21-6
Molecular Formula	C9H11FN2O6
Molecular Weight	262.19 g/mol
Synonyms	5-Fluorouridine; 1-β-D-Ribofuranosyl-5-fluorouracil; 5-Fluoro-1-β-D-ribofuranosyluracil; 5-FUrd; 5-Fluorouridine, 1-β-D-Ribofuranosyl-5-fluorouracil; 5-Fluoro-1-β-D-ribosyluracil; NSC 33001
EINECS	242-593-1

Quality Control

Our 5-Fluorouridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.