Description

3'-Chloro-3'-Deoxyuridine is a halogenated nucleoside analog with significant biochemical and pharmaceutical research applications. This compound is valued for its role as a key synthetic intermediate and a potential building block for modified oligonucleotides. It is primarily utilized by research institutions and pharmaceutical companies engaged in antiviral and anticancer drug discovery, as well as in biochemical studies exploring nucleic acid metabolism and enzyme inhibition.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate the mechanisms of thymidine kinase and other nucleoside-metabolizing enzymes.
• Antiviral Studies: Investigated for its potential activity against various DNA viruses due to its structural similarity to natural nucleosides.
• Oligonucleotide Synthesis: Acts as a modified monomer for incorporating specific functionalities into synthetic DNA or RNA strands for diagnostic or therapeutic applications.
• Metabolic Pathway Analysis: Employed as a tracer or probe to study nucleoside salvage pathways and DNA synthesis in cellular models.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	3'-Chloro-3'-Deoxyuridine
CAS No.	18810-36-1
Molecular Formula	C9H11ClN2O5
Molecular Weight	262.65 g/mol
Synonyms	3'-Chloro-2',3'-dideoxyuridine; 1-((2R,5S)-5-Chloro-2,5-dihydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 3'-Chloro-2',3'-dideoxyuridine; 3'-Cl-3'-dUrd; NSC 382487; 3'-Chloro-3'-deoxy-uridine; 2',3'-Dideoxy-3'-chlorouridine
EINECS	Contact for details

Quality Control

Our 3'-Chloro-3'-Deoxyuridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.