Description

2'-Deoxy-5'-o-(Triphenylmethyl)Cytidine is a key nucleoside derivative where the 5'-hydroxyl group is protected by a trityl (triphenylmethyl) moiety. This compound matters as a crucial building block in the chemical synthesis of oligonucleotides, enabling precise control over nucleic acid sequences. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of antisense oligonucleotides, primers, and other advanced therapeutic nucleic acid analogs.

Application

• Oligonucleotide Synthesis: Serves as a critical phosphoramidite precursor in solid-phase synthesis for research and therapeutic applications.
• Antisense Drug Development: Used in the manufacture of antisense oligonucleotides targeting specific mRNA sequences.
• Primer and Probe Manufacturing: Essential for producing labeled primers and probes used in PCR, sequencing, and diagnostic assays.
• Chemical Biology Research: A valuable intermediate for studying nucleic acid structure, function, and for creating modified nucleosides.
• Pharmaceutical Intermediates: Acts as a protected intermediate in the multi-step synthesis of complex nucleoside-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2'-Deoxy-5'-o-(Triphenylmethyl)Cytidine
CAS No.	18531-20-9
Molecular Formula	C30H29N3O4
Molecular Weight	495.57 g/mol
Synonyms	5'-O-Trityl-2'-deoxycytidine; 5'-O-(Triphenylmethyl)-2'-deoxycytidine; N4-Benzoyl-5'-O-trityl-2'-deoxycytidine (common protected form); dC(Tr) (abbreviation); 1-(5-O-Triphenylmethyl-2-deoxy-β-D-erythro-pentofuranosyl)-4-aminopyrimidin-2(1H)-one; Cytidine, 2'-deoxy-5'-O-(triphenylmethyl)-; 5'-O-Trityldeoxycytidine
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-5'-o-(Triphenylmethyl)Cytidine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.