Description

5'-Trt-N6-Bz-Ra is a protected nucleoside derivative, specifically a ribavirin analog, where the 5'-hydroxyl group is protected by a trityl (Trt) group and the N6-amino group is protected by a benzoyl (Bz) group. This compound is a critical building block in the synthesis of modified nucleosides and oligonucleotides, enabling advanced research in antiviral drug development and nucleic acid chemistry. It is essential for pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on creating novel therapeutic agents and molecular probes.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used in solid-phase synthesis for the controlled incorporation of modified ribavirin units into RNA strands.
• Biochemical Research: Employed in studies investigating RNA virus replication mechanisms and the design of nucleotide-based inhibitors.
• Pro-drug Development: Acts as a protected form for the targeted delivery and activation of ribavirin-related compounds.
• Antiviral Screening: Utilized as a standard or building block in high-throughput screening assays for new antiviral candidates.
• Chemical Biology: Facilitates the creation of labeled or tagged nucleosides for tracking and imaging studies within biological systems.

Basic Information

Product Name	5'-Trt-N6-Bz-Ra
CAS No.	18404-90-5
Molecular Formula	C32H31N5O5
Molecular Weight	565.62 g/mol
Synonyms	1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-((trityloxy)methyl)tetrahydrofuran-2-yl)-1H-1,2,4-triazole-3-carboxamide, N6-Benzoyl-5'-O-tritylribavirin; 5'-O-Trityl-N6-benzoylribavirin; N6-Benzoyl-5'-O-trityl-1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide; Ribavirin, N6-benzoyl-5'-O-trityl-; 1-(2,3,5-Tri-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide (related protected form)
EINECS	Contact for details

Quality Control

Our 5'-Trt-N6-Bz-Ra is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.