Description

1-(Trimethylsilyl)-1-Pentyne is a specialized organosilicon compound featuring a terminal alkyne group protected by a trimethylsilyl (TMS) moiety. This unique structure makes it a valuable synthetic building block and reactive intermediate in advanced organic synthesis, particularly for cross-coupling and cycloaddition reactions. It is essential for R&D and production in the pharmaceutical, agrochemical, and advanced materials sectors, where precise molecular construction is critical.

Application

• Pharmaceutical Intermediate: Used in the synthesis of complex drug molecules, particularly in Sonogashira and other palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Agrochemical Synthesis: Serves as a key precursor for creating novel active ingredients with specific biological activity.
• Material Science: Employed in the development of organic semiconductors, liquid crystals, and polymers with tailored electronic or optical properties.
• Organic Synthesis Reagent: Acts as a protected acetylene equivalent in multi-step syntheses, allowing for selective deprotection and further functionalization.
• Research & Development: A crucial tool in academic and industrial laboratories for exploring new synthetic methodologies and creating novel chemical entities.

Basic Information

Product Name	1-(Trimethylsilyl)-1-Pentyne
CAS No.	18270-17-2
Molecular Formula	C8H16Si
Molecular Weight	140.30 g/mol
Synonyms	1-Pentyne, 1-(trimethylsilyl)-; Trimethyl(1-pentyn-1-yl)silane; 1-Trimethylsilyl-1-pentyne; 1-Pentynyltrimethylsilane; TMS-Pentyne; (Pent-1-yn-1-yl)trimethylsilane; Silane, trimethyl(1-pentyn-1-yl)-; 18270-17-2
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilyl)-1-Pentyne is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC, NMR, and FTIR, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality systems are designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent evaporation and degradation. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.