Description

3-(Trimethylsilyl)Propanoyl Chloride is a versatile organosilicon reagent featuring a reactive acid chloride group protected by a trimethylsilyl moiety. This compound is valued for its role as a key building block in organic synthesis, enabling the introduction of functionalized silyl groups into target molecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of complex intermediates and active ingredients.

Application

• Pharmaceutical Intermediate: A crucial reagent for the synthesis of active pharmaceutical ingredients (APIs), particularly in constructing silicon-containing drug candidates or as a protecting group strategy.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where the silyl group modifies the biological activity or stability of the compound.
• Polymer & Material Science: Serves as a monomer or functionalization agent for creating specialty silicones, surface modifiers, and advanced polymeric materials with tailored properties.
• Cross-Coupling Reactions: Acts as an electrophile in various metal-catalyzed coupling reactions to form carbon-silicon bonds.
• Peptide & Protein Modification: Employed to introduce silyl-protected carboxylic acid functionalities into peptides or biomolecules.
• Liquid Crystal & OLED Material Production: Used in the synthesis of organosilicon components for electronic displays and organic light-emitting diodes.

Basic Information

Product Name	3-(Trimethylsilyl)Propanoyl Chloride
CAS No.	18187-31-0
Molecular Formula	C6H13ClOSi
Molecular Weight	164.70 g/mol
Synonyms	3-(Trimethylsilyl)propionyl chloride; Trimethylsilylpropionyl chloride; 3-(Trimethylsilyl)propanoic acid chloride; β-(Trimethylsilyl)propionyl chloride; TMS-propionyl chloride; (3-Chloroformylpropyl)trimethylsilane; 3-(Trimethylsilyl)propanoyl chloride; 18187-31-0
EINECS	Contact for details

Quality Control

Our 3-(Trimethylsilyl)Propanoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at temperatures between 2°C and 8°C (refrigerated) or as specified for specific grades. This product is hygroscopic (moisture-sensitive) and reacts vigorously with water, strong bases, and alcohols. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.