Description

1-(Trimethylsilyl)-1H-Pyrazole is a versatile organosilicon reagent featuring a protected pyrazole ring, widely utilized as a key building block in advanced organic synthesis. Its primary value lies in its role as a silylating agent and a stable heterocyclic precursor, enabling the efficient construction of complex molecules in controlled environments. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries, where it facilitates the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a crucial synthon in the synthesis of novel drug candidates, particularly in constructing nitrogen-containing heterocycles common in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the development of modern pesticides and herbicides, where the pyrazole moiety contributes to biological activity.
• Ligand & Catalyst Preparation: Acts as a precursor for N-heterocyclic carbene (NHC) ligands and other organometallic catalysts used in cross-coupling and polymerization reactions.
• Material Science: Employed in the surface functionalization of silicon-based materials and as a monomer or additive in specialty polymer systems.
• Protecting Group Chemistry: The trimethylsilyl (TMS) group protects the pyrazole nitrogen, allowing for selective reactions at other sites on the molecule during multi-step syntheses.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry and scale-up process optimization.

Basic Information

Product Name	1-(Trimethylsilyl)-1H-Pyrazole
CAS No.	18156-75-7
Molecular Formula	C6H12N2Si
Molecular Weight	140.26 g/mol
Synonyms	1-(Trimethylsilyl)pyrazole; 1H-Pyrazole, 1-(trimethylsilyl)-; Pyrazole, 1-(trimethylsilyl)-; Trimethyl(pyrazol-1-yl)silane; 1-TMS-pyrazole; N-Trimethylsilylpyrazole; (Pyrazol-1-yl)trimethylsilane; 1-Trimethylsilyl-1H-pyrazole
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilyl)-1H-Pyrazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatographic purity assays and identity confirmation, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) documenting purity, physical properties, and test results are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.