Description

n-(Trimethylsilyl)Imidazole is a versatile organosilicon reagent primarily used as a silylating agent and protective group intermediate in organic synthesis. Its high reactivity makes it a critical component for introducing the trimethylsilyl (TMS) group, which is essential for modifying compound solubility, stability, and reactivity. This product is indispensable for research and production in the pharmaceutical, agrochemical, and advanced materials sectors, where precise chemical functionalization is required.

Application

• Pharmaceutical Synthesis: Used as a silylating agent to protect hydroxyl and amino groups during the multi-step synthesis of active pharmaceutical ingredients (APIs) and complex drug molecules.
• Agrochemical Manufacturing: Serves as a key intermediate in the production of pesticides, herbicides, and fungicides, where it aids in creating specific bioactive structures.
• Polymer & Material Science: Employed in the surface modification of silica and other inorganic materials, and as a precursor for silicone-based polymers and advanced composites.
• Analytical Chemistry: Utilized as a derivatization agent in gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) to enhance the volatility and detectability of polar compounds.
• Organic Synthesis Reagent: A fundamental building block for synthesizing various silyl ethers and silyl amines, facilitating a wide range of nucleophilic substitution and condensation reactions.

Basic Information

Product Name	n-(Trimethylsilyl)Imidazole
CAS No.	18156-74-6
Molecular Formula	C6H12N2Si
Molecular Weight	140.26 g/mol
Synonyms	1-(Trimethylsilyl)-1H-imidazole; 1-(Trimethylsilyl)imidazole; TMS-Imidazole; Imidazole, 1-(trimethylsilyl)-; N-Trimethylsilylimidazole; Trimethylsilylimidazole; 1-Trimethylsilylimidazole; Silane, (1H-imidazol-1-yl)trimethyl-
EINECS	242-059-1

Quality Control

Our n-(Trimethylsilyl)Imidazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee compliance with your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is highly volatile and hygroscopic (moisture-sensitive). It must be kept under an inert atmosphere (e.g., nitrogen or argon) and handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.