Description

5'-o-Triphenylmethyl-Adenosine is a key nucleoside derivative where the 5'-hydroxyl group of adenosine is protected by a trityl (triphenylmethyl) moiety. This modification is critical for its primary role as a versatile building block in the solid-phase synthesis of oligonucleotides, enabling precise control over nucleic acid sequences. It is an essential raw material for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing antisense oligonucleotides, siRNA, and other advanced therapeutic nucleic acids.

Application

• Oligonucleotide Synthesis: A fundamental phosphoramidite precursor for the automated solid-phase synthesis of DNA and RNA strands.
• Antisense Therapy Development: Used in the research and production of antisense oligonucleotides for targeted gene silencing.
• siRNA and miRNA Synthesis: Serves as a protected adenosine monomer for constructing short interfering RNA (siRNA) and microRNA (miRNA) molecules.
• Pharmaceutical Intermediates: Acts as a critical intermediate in the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Diagnostic Probe Manufacturing: Employed in the creation of labeled nucleic acid probes for diagnostic assays and genomic research.
• Bioconjugation: The trityl protecting group allows for selective deprotection and subsequent conjugation with other molecules.

Basic Information

Product Name	5'-o-Triphenylmethyl-Adenosine
CAS No.	18048-85-6
Molecular Formula	C31H29N5O4
Molecular Weight	535.60 g/mol
Synonyms	5'-O-Trityladenosine; N6-Benzoyl-5'-O-(triphenylmethyl)adenosine (common protected form); 5'-O-(Triphenylmethyl)adenosine; Trityl Adenosine; Adenosine, 5'-O-trityl-; 9-β-D-Ribofuranosyladenine, 5'-O-trityl-; 5'-Trityl-adenosine
EINECS	Contact for details

Quality Control

Our 5'-o-Triphenylmethyl-Adenosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for sensitive oligonucleotide synthesis. Certificates of Analysis (COA) detailing purity, moisture content, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.