Description

(20R)-17α,20-Dihydroxycholesterol CAS NO 17913-42-7 is a high-purity, synthetic oxysterol derivative of cholesterol, serving as a critical intermediate and reference standard in advanced biochemical research. This compound matters for its role in studying steroid hormone biosynthesis, lipid metabolism, and specific signaling pathways within the body. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of diagnostic reagents focused on endocrinology and metabolic disease studies.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of more complex steroid-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a reference standard and substrate in enzymatic studies related to cytochrome P450 enzymes and other hydroxylases.
• Metabolic Pathway Analysis: Critical for investigating the biosynthesis and regulation of steroid hormones, including corticosteroids and sex hormones.
• Cell Signaling Studies: Employed in research on liver X receptor (LXR) and other nuclear receptor signaling pathways influenced by oxysterols.
• Diagnostic Reagent Manufacturing: Serves as a calibrant or component in the production of assay kits for clinical and research laboratories.
• Academic & Institutional Research: A fundamental tool for universities and research institutes studying lipid biology, endocrinology, and related disorders.

Basic Information

Product Name	(20R)-17α,20-Dihydroxycholesterol
CAS No.	17913-42-7
Molecular Formula	C27H46O3
Molecular Weight	418.66 g/mol
Synonyms	(20R)-Cholest-5-ene-3β,17α,20-triol; 17α,20α-Dihydroxycholesterol; 20(R)-17α,20-Dihydroxycholesterol; 3β,17α,20α-Trihydroxy-5-cholestene; 5-Cholestene-3β,17α,20α-triol; (20R)-17α,20α-Dihydroxycholesterol; 17α,20α-Dihydroxy-5-cholesten-3β-ol
EINECS	Contact for details

Quality Control

Our (20R)-17α,20-Dihydroxycholesterol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. For long-term storage, desiccate at -20°C. The container should be kept in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Solvent Residue (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.