Description

16β-Hydroxypregn-4-Ene-3,20-Dione is a high-purity steroid intermediate of significant importance in pharmaceutical synthesis. This compound serves as a critical building block for the development of advanced steroid-based therapeutics, offering a key chiral center for further chemical modification. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of corticosteroids, progestogens, and other specialized hormone analogs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potent corticosteroid and progestogen APIs (Active Pharmaceutical Ingredients).
• Steroid Research: Used as a reference standard and starting material in academic and industrial research exploring new steroid derivatives and their biological activities.
• Process Development: Employed in the scale-up and optimization of synthetic routes for complex steroid molecules within process chemistry.
• Biochemical Studies: Utilized in studies investigating steroid hormone metabolism, receptor binding, and enzymatic conversion pathways.

Basic Information

Product Name	16β-Hydroxypregn-4-Ene-3,20-Dione
CAS No.	17779-71-4
Molecular Formula	C21H30O3
Molecular Weight	330.46 g/mol
Synonyms	16β-Hydroxyprogesterone; 16β-Hydroxypregn-4-ene-3,20-dione; 16β-OH-P4; (16β)-16-Hydroxypregn-4-ene-3,20-dione; 16β-Hydroxy-4-pregnene-3,20-dione; 16β-Hydroxypregnenedione
EINECS	Contact for details

Quality Control

Our 16β-Hydroxypregn-4-Ene-3,20-Dione is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with detailed chromatographic data and full traceability. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.