Description

N1-Methyl Ara-Uridine is a chemically modified nucleoside analog, a key building block in advanced oligonucleotide synthesis. This compound is crucial for the development and research of modified RNA and DNA strands, where it can be incorporated to alter stability, binding affinity, and biological activity. It is primarily utilized by researchers and manufacturers in the fields of pharmaceutical development, antisense therapy, and diagnostic probe design.

Application

• Oligonucleotide Synthesis: A critical phosphoramidite precursor for the solid-phase synthesis of modified RNA and DNA strands.
• Antisense & siRNA Therapeutics: Used to incorporate specific modifications that enhance nuclease resistance and target affinity in therapeutic oligonucleotides.
• Structural Biology Studies: Serves as a probe to investigate RNA structure, function, and protein-RNA interactions.
• Diagnostic Assay Development: Employed in the creation of labeled probes for sensitive detection systems like qPCR and FISH.
• Medicinal Chemistry Research: Acts as a scaffold for developing novel nucleoside-based antiviral or anticancer agents.
• Bioconjugation: Provides a reactive handle for attaching reporter molecules, such as fluorophores or affinity tags, to oligonucleotides.

Basic Information

Product Name	N1-Methyl Ara-Uridine
CAS No.	17676-62-9
Molecular Formula	C10H14N2O6
Molecular Weight	258.23 g/mol
Synonyms	1-Methyl-β-D-arabinofuranosyluracil; 1-MethylaraU; 1-Methyl-β-D-arabinosyluracil; N(1)-Methyl-β-D-arabinofuranosyluracil; 1-Methyl-β-D-arabinofuranosyl-2,4(1H,3H)-pyrimidinedione; Ara-Uridine, N1-methyl-; 1-Methyl-D-arabinosyluracil
EINECS	Contact for details

Quality Control

Our N1-Methyl Ara-Uridine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and MS. We provide full traceability and Certificates of Analysis (COA) are available for every shipment to ensure compliance with your research and cGMP-grade manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.