Description

(20S)-3α,20-Bis(Trimethylsiloxy)-5β-Pregnan-17-Ol CAS NO 17562-94-6 is a high-purity, organosilicon-modified pregnane derivative, a key intermediate in advanced pharmaceutical synthesis. Its value lies in providing a protected steroid framework essential for the efficient production of complex therapeutic agents. This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of steroid-based drugs, hormone therapies, and other specialized bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of steroidal active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for the discovery and optimization of new steroid receptor modulators.
• Hormone Analog Synthesis: Serves as a precursor for creating novel analogs of pregnane-based hormones with tailored biological activity.
• Process Chemistry: Employed in scale-up and process optimization for the commercial manufacturing of steroid drugs.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(20S)-3α,20-Bis(Trimethylsiloxy)-5β-Pregnan-17-Ol
CAS No.	17562-94-6
Molecular Formula	C29H54O3Si2
Molecular Weight	506.91 g/mol
Synonyms	5β-Pregnan-17-ol, 3,20-bis[(trimethylsilyl)oxy]-, (3α,5β,20S)-; (20S)-3α,20-Bis(trimethylsiloxy)-5β-pregnan-17-ol; 3α,20α-Bis(trimethylsiloxy)-5β-pregnan-17β-ol; 17-Hydroxy-5β-pregnane-3,20-diyl bis(trimethylsilyl) ether; Pregnane-3,20-diol bis(trimethylsilyl) ether; TMS-protected pregnanediol derivative
EINECS	Contact for details

Quality Control

Our (20S)-3α,20-Bis(Trimethylsiloxy)-5β-Pregnan-17-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided to guarantee the material meets the stringent requirements for pharmaceutical R&D and cGMP intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.