Description

3α,11β-Bis(Trimethylsiloxy)-5α-Androstan-17-One is a high-purity, synthetic steroid derivative characterized by its trimethylsilyl-protected hydroxyl groups at the 3 and 11 positions. This compound serves as a critical advanced pharmaceutical intermediate for the research and development of novel steroid-based therapeutics. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex steroid drugs and hormone analogs.
• Research & Development: Used in medicinal chemistry for the discovery and optimization of new therapeutic agents targeting hormone receptors.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry: Employed in scale-up and process optimization for the commercial production of steroid-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Utilized in studies investigating steroid metabolism, enzyme inhibition, and structure-activity relationships (SAR).

Basic Information

Product Name	3α,11β-Bis(Trimethylsiloxy)-5α-Androstan-17-One
CAS No.	17562-92-4
Molecular Formula	C25H46O3Si2
Molecular Weight	450.81 g/mol
Synonyms	3α,11β-Bis(trimethylsilyloxy)-5α-androstan-17-one; 5α-Androstan-17-one, 3α,11β-bis[(trimethylsilyl)oxy]-; 3α,11β-Di-O-trimethylsilyl-5α-androstan-17-one; Androstane-3α,11β-diol 17-one bis(trimethylsilyl) ether; 3α,11β-Bis-O-TMS-5α-androstan-17-one; 17562-92-4; Steroid silyl ether intermediate
EINECS	Contact for details

Quality Control

Our 3α,11β-Bis(Trimethylsiloxy)-5α-Androstan-17-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.