Description

1-(3-Aminophenyl)-2,2,2-Trifluoroethan-1-Ol is a versatile aromatic amine derivative containing a trifluoromethyl carbinol group. This unique structure makes it a valuable high-purity building block for advanced organic synthesis, particularly in the development of complex molecules. It is primarily sought after by pharmaceutical, agrochemical, and specialty chemical R&D sectors for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially those requiring fluorinated aromatic scaffolds to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts in asymmetric synthesis, leveraging the amine and alcohol functionalities.
• Material Science Research: Employed in the synthesis of specialty polymers, liquid crystals, and advanced organic frameworks (MOFs/COFs) for electronic or optical applications.
• Fluorine Chemistry Building Block: Essential for introducing the trifluoroethanol moiety into complex molecules, a common motif in medicinal and agrochemical discovery.

Basic Information

Product Name	1-(3-Aminophenyl)-2,2,2-Trifluoroethan-1-Ol
CAS No.	17556-38-6
Molecular Formula	C8H8F3NO
Molecular Weight	191.15 g/mol
Synonyms	3-(1-Hydroxy-2,2,2-trifluoroethyl)aniline; 3-Amino-α-(trifluoromethyl)benzyl alcohol; 1-(3-Aminophenyl)-2,2,2-trifluoroethanol; m-Amino-α-(trifluoromethyl)benzyl alcohol; 3-(2,2,2-Trifluoro-1-hydroxyethyl)aniline; α-(Trifluoromethyl)-3-aminobenzyl alcohol
EINECS	Contact for details

Quality Control

Our 1-(3-Aminophenyl)-2,2,2-Trifluoroethan-1-Ol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC, GC, NMR, and FTIR to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates for research and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.