Description

2'-O,3'-o-Isopropylidene-4',5'-Didehydro-5'-Deoxyuridine is a sophisticated nucleoside analog derivative, serving as a crucial advanced intermediate in modern pharmaceutical synthesis. Its primary value lies in its protected ribose moiety, which is essential for the targeted synthesis of novel antiviral and anticancer nucleoside therapeutics. This high-purity building block is indispensable for research institutions and pharmaceutical manufacturers engaged in developing next-generation antiviral drugs, mRNA-related therapeutics, and nucleotide-based prodrugs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Antiviral Drug Research: Used in the development of prodrugs and active pharmaceutical ingredients (APIs) targeting viral polymerases.
• Oncology Research: Serves as a precursor for nucleotide analogs designed to inhibit cancer cell proliferation.
• mRNA Technology & Oligonucleotide Synthesis: Valuable intermediate for modifying nucleosides used in therapeutic oligonucleotides and mRNA cap analogs.
• Medicinal Chemistry & Process Development: Enables structure-activity relationship (SAR) studies and scalable synthetic route development for new chemical entities.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism.

Basic Information

Product Name	2'-O,3'-o-Isopropylidene-4',5'-Didehydro-5'-Deoxyuridine
CAS No.	17331-67-8
Molecular Formula	C₁₂H₁₄N₂O₅
Molecular Weight	266.25 g/mol
Synonyms	4',5'-Didehydro-5'-deoxy-2',3'-O-isopropylideneuridine; 2',3'-O-Isopropylidene-4',5'-didehydro-5'-deoxyuridine; 5'-Deoxy-2',3'-O-isopropylidene-4',5'-didehydro-5'-deoxyuridine; 4',5'-Unsaturated uridine derivative; Isopropylidene-protected didehydrodeoxyuridine; Nucleoside intermediate 17331-67-8
EINECS	Contact for details

Quality Control

Our 2'-O,3'-o-Isopropylidene-4',5'-Didehydro-5'-Deoxyuridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research and development. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A detailed Certificate of Analysis (COA) is supplied with each batch, documenting identity, purity, and impurity profiles to support regulatory filings and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.