Description

Thymidine 3'-Benzoate CAS NO 17331-53-2 is a chemically modified nucleoside derivative where a benzoate group is esterified at the 3'-hydroxyl position of the thymidine sugar moiety. This modification is critical for its primary role as a key synthetic intermediate and protecting group in the production of oligonucleotides, nucleoside analogs, and other fine chemicals. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing antiviral agents, anticancer drugs, and molecular probes. The compound's specific structure allows for controlled chemical transformations, making it valuable for advanced organic synthesis.

Application

• Oligonucleotide Synthesis: Serves as a crucial protected intermediate in the solid-phase and solution-phase synthesis of DNA and RNA sequences.
• Pharmaceutical Intermediates: Used in the research and production of nucleoside-based antiviral and anticancer drugs.
• Biochemical Research: Acts as a substrate or precursor in enzymatic studies and for probing nucleic acid metabolism.
• Protecting Group Chemistry: The benzoate group provides selective protection for the 3'-hydroxyl during multi-step synthetic routes.
• Labeled Compound Synthesis: A starting material for the preparation of isotopically labeled (e.g., C13, N15) nucleosides for tracer studies.
• Academic & Industrial R&D: Employed in laboratories for developing novel therapeutic agents and diagnostic tools.

Basic Information

Product Name	Thymidine 3'-Benzoate
CAS No.	17331-53-2
Molecular Formula	C17H18N2O6
Molecular Weight	346.34 g/mol
Synonyms	1-(3-O-Benzoyl-2-deoxy-β-D-ribofuranosyl)thymine; 3'-O-Benzoylthymidine; Thymidine 3'-monobenzoate; 2'-Deoxythymidine 3'-benzoate; 3'-Bz-Thd; 1-[3-O-(Benzoyl)-2-deoxy-β-D-erythro-pentofuranosyl]-5-methyl-2,4(1H,3H)-pyrimidinedione; 3'-O-Benzoyl-2'-deoxythymidine
EINECS	Contact for details

Quality Control

Our Thymidine 3'-Benzoate is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and synthesis applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, IR). A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We support compliance with cGMP and ISO 9001 standards for pharmaceutical intermediate manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.