Description

2'-Deoxy-N2-Dimethylaminomethylene-Guanosine is a chemically modified nucleoside derivative, serving as a crucial protected intermediate in oligonucleotide synthesis. This compound matters for its role in enabling the precise construction of DNA sequences, where it protects the guanine base during automated solid-phase synthesis. It is primarily needed by research institutions, pharmaceutical developers, and biotechnology companies engaged in antisense therapy development, diagnostic probe manufacturing, and fundamental genetic research.

Application

• Oligonucleotide Synthesis: As a key phosphoramidite building block for the automated synthesis of DNA strands.
• Antisense Drug Development: For the research and production of therapeutic oligonucleotides targeting specific mRNA sequences.
• Diagnostic Probe Fabrication: Used in creating labeled probes for techniques like FISH (Fluorescence In Situ Hybridization) and PCR.
• Genetic Research: A fundamental reagent in molecular biology for studying gene function and regulation.
• Pharmaceutical Intermediates: Serves as a protected precursor in the synthesis of more complex nucleoside-based active pharmaceutical ingredients (APIs).
• Bioconjugation: The modified exocyclic amine can be utilized for further chemical modifications and attachment of reporter molecules.

Basic Information

Product Name	2'-Deoxy-N2-Dimethylaminomethylene-Guanosine
CAS No.	17331-13-4
Molecular Formula	C13H18N6O4
Molecular Weight	322.32 g/mol
Synonyms	N2-(Dimethylaminomethylene)-2'-deoxyguanosine; 2'-Deoxy-N2-[(dimethylamino)methylene]guanosine; dG(DMF); Guanosine, 2'-deoxy-N2-[(dimethylamino)methylene]-; N2-DMF-dG; Protected 2'-Deoxyguanosine; DMF-protected deoxyguanosine
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-N2-Dimethylaminomethylene-Guanosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.