Description

3',5'-Di-o-Acetyl-2'-Deoxyadenosine is a key protected nucleoside derivative, essential for the controlled synthesis of oligonucleotides and nucleotide analogs. This compound serves as a critical building block in pharmaceutical research and development, enabling the creation of novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical manufacturers, and biotechnology companies engaged in the development of antiviral drugs, anticancer agents, and molecular diagnostics. Its role is fundamental in ensuring precise and efficient chemical modifications during complex synthesis processes.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of nucleoside-based antiviral and anticancer drugs.
• Oligonucleotide Synthesis: Used as a protected monomer in solid-phase and solution-phase synthesis of DNA and RNA analogs.
• Biochemical Research: Employed in studies of enzyme mechanisms, nucleic acid chemistry, and metabolic pathways.
• Prodrug Development: Acts as a masked form of 2'-deoxyadenosine to improve bioavailability and stability in drug formulations.
• Diagnostic Probe Synthesis: Utilized in the creation of labeled nucleotides for use in diagnostic assays and genomic sequencing.
• Academic & Industrial R&D: Serves as a standard reagent in laboratories focused on medicinal chemistry and molecular biology.

Basic Information

Product Name	3',5'-Di-o-Acetyl-2'-Deoxyadenosine
CAS No.	17318-24-0
Molecular Formula	C₁₄H₁₇N₅O₅
Molecular Weight	335.32 g/mol
Synonyms	2'-Deoxyadenosine 3',5'-diacetate; N6-Adenine-2'-deoxyriboside 3',5'-diacetate; 9-[(2R,3S,5R)-3,5-Diacetoxy-2-(hydroxymethyl)tetrahydrofuran-2-yl]-9H-purin-6-amine; 3',5'-Diacetyl-2'-deoxyadenosine; 2'-Deoxy-3',5'-di-O-acetyladenosine; DA-3',5'-diAc; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 3',5'-Di-o-Acetyl-2'-Deoxyadenosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or production specifications. Our quality commitment supports applications requiring high-purity biochemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Solvent Residues (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.