Description

2'-Deoxy-8-Methoxyadenosine is a modified nucleoside analog of significant interest in advanced biochemical research and pharmaceutical development. Its unique structure, featuring a methoxy group at the 8-position of the adenine ring, makes it a valuable building block for studying nucleic acid interactions and designing novel therapeutic agents. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of oligonucleotides, antiviral drug discovery, and the exploration of epigenetic mechanisms.

Application

• Oligonucleotide Synthesis: A key intermediate for the preparation of modified DNA strands for research, diagnostics, and therapeutic applications.
• Antiviral Research: Investigated as a potential precursor or analog in the development of nucleoside-based antiviral agents.
• Biochemical Probes: Used to study enzyme mechanisms, particularly those involving adenosine deaminases and other nucleic acid-modifying enzymes.
• Pharmaceutical Intermediate: Serves as a critical starting material or advanced intermediate in the synthesis of more complex active pharmaceutical ingredients (APIs).
• Academic & Industrial R&D: Employed in basic research to understand structure-activity relationships (SAR) of nucleoside analogs.

Basic Information

Product Name	2'-Deoxy-8-Methoxyadenosine
CAS No.	17318-17-1
Molecular Formula	C11H15N5O4
Molecular Weight	281.27 g/mol
Synonyms	8-Methoxy-2'-deoxyadenosine; 8-Methoxy-deoxyadenosine; 2'-Deoxy-8-methoxyadenosine; 9-(2-Deoxy-β-D-erythro-pentofuranosyl)-8-methoxy-9H-purin-6-amine; 8-Methoxy-2'-deoxyadenosine; 8-Methoxy-2'-deoxyadenosine (8-MeO-dA)
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-8-Methoxyadenosine is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP guidelines for the manufacture of advanced pharmaceutical intermediates, ensuring traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.