Description

O,O'-Bis(Trimethylsilyl)-5-Fluorouracil is a silylated derivative of the potent chemotherapeutic agent 5-fluorouracil, designed to enhance its stability and handling properties for advanced synthetic applications. This compound serves as a crucial protected intermediate, enabling precise chemical modifications in the development of novel active pharmaceutical ingredients (APIs) and nucleoside analogs. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of next-generation anticancer and antiviral therapeutics, where high-purity, moisture-sensitive building blocks are essential.

Application

• Pharmaceutical Intermediate: A key protected synthon in the multi-step synthesis of novel fluoropyrimidine-based anticancer drugs and prodrugs.
• Nucleoside Chemistry Research: Used in academic and industrial R&D for modifying nucleoside structures to study structure-activity relationships and develop new therapeutic agents.
• Antiviral Drug Development: Serves as a building block in the creation of experimental antiviral compounds that target viral DNA or RNA synthesis.
• Process Chemistry & Scale-up: Employed in process development and optimization for the commercial manufacturing of fluorouracil-derived APIs, where its silyl groups offer improved solubility and reaction selectivity.
• Chemical Biology Probes: Utilized in the synthesis of labeled or tagged fluorouracil derivatives for biochemical and pharmacological studies, such as mechanism-of-action research.

Basic Information

Product Name	O,O'-Bis(Trimethylsilyl)-5-Fluorouracil
CAS No.	17242-85-2
Molecular Formula	C11H21FN2O2Si2
Molecular Weight	288.46 g/mol
Synonyms	5-Fluoro-2,4-bis(trimethylsiloxy)pyrimidine; 5-Fluorouracil O,O'-bis(trimethylsilyl) ether; 1,3-Bis(trimethylsilyl)-5-fluorouracil; 5-FU bis(trimethylsilyl) ether; BTS-FU; 5-Fluorouracil bis(trimethylsilyl) derivative; N,O-Bis(trimethylsilyl)-5-fluorouracil; 2,4-Bis(trimethylsiloxy)-5-fluoropyrimidine
EINECS	Contact for details

Quality Control

Our O,O'-Bis(Trimethylsilyl)-5-Fluorouracil is manufactured under controlled conditions to ensure batch-to-batch consistency and high chemical purity suitable for research and pharmaceutical synthesis. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, NMR, and FTIR. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.