Description

3β-Hydroxy-5β-Carda-8,20(22)-Dienolide is a high-purity cardenolide derivative, a specialized class of steroid compounds with significant biological activity. This compound serves as a critical intermediate and reference standard in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents and in-depth pharmacological studies.

Application

• Pharmaceutical Intermediate: A key building block in the synthetic pathways for novel cardiac glycosides and other steroidal drugs.
• Reference Standard: Used in analytical laboratories for the identification, purity assessment, and quantification of cardenolides via HPLC, LC-MS, or NMR.
• Biochemical Research: Employed in studies investigating the structure-activity relationships (SAR) of cardenolides and their interaction with biological targets like the Na+/K+-ATPase pump.
• Natural Product Synthesis: Serves as a precursor in the semi-synthesis of complex natural products derived from plant sources like Digitalis.
• Metabolite Studies: Used as an analytical standard in pharmacokinetic and metabolic profiling research for cardiotonic drugs.

Basic Information

Product Name	3β-Hydroxy-5β-Carda-8,20(22)-Dienolide
CAS No.	17149-54-1
Molecular Formula	C23H32O4
Molecular Weight	372.50 g/mol
Synonyms	3β-Hydroxy-5β-carda-8,20(22)-dienolide; 3β-Hydroxy-14-oxo-5β-card-8,20(22)-dienolide; 3β-Hydroxy-5β,14β-card-8,20(22)-dienolide; 3-Epigitoxigenin; 3-Epi-gitoxigenin; 3-Epigitoxigenin (ambiguous); Card-8,20(22)-dienolide, 3β-hydroxy-5β-
EINECS	Contact for details

Quality Control

Our 3β-Hydroxy-5β-Carda-8,20(22)-Dienolide is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.