Description

1,3-Dihydro-1,3-Dioxo-2H-Isoindole-2-Propionyl Chloride is a high-purity, reactive chemical intermediate essential for advanced organic synthesis. Its value lies in its role as a versatile acylating and coupling agent, enabling the efficient introduction of the phthalimidoacetyl moiety into target molecules. This compound is critically needed by research and development laboratories and production facilities in the pharmaceutical and agrochemical sectors for constructing complex active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing phthalimide-protected amine functionalities.
• Peptide Synthesis: Used as an acylating agent in peptide coupling reactions to incorporate specific side chains or protecting groups.
• Agrochemical Production: Intermediate in the manufacture of advanced herbicides, fungicides, and plant growth regulators.
• Organic Synthesis Reagent: Employed in academic and industrial R&D for constructing heterocyclic compounds and other complex organic structures.
• Polymer Chemistry: Can be utilized to modify polymers or create specialized monomers with specific functional properties.
• Bioconjugation: Potential use in linking small molecules to proteins or other biomolecules for research and diagnostic applications.

Basic Information

Product Name	1,3-Dihydro-1,3-Dioxo-2H-Isoindole-2-Propionyl Chloride
CAS No.	17137-11-0
Molecular Formula	C11H8ClNO3
Molecular Weight	237.64 g/mol
Synonyms	2-(2-Chloro-1-oxoethyl)isoindoline-1,3-dione; N-(Chloroacetyl)phthalimide; Phthalimidoylacetyl Chloride; 2-(Chloroacetyl)phthalimide; 2-(Chloroacetyl)-1H-isoindole-1,3(2H)-dione; N-Chloroacetylphthalimide; 1,3-Dioxo-2-isoindolinepropionyl Chloride; Phthalimidoacetyl Chloride
EINECS	241-186-5

Quality Control

Our 1,3-Dihydro-1,3-Dioxo-2H-Isoindole-2-Propionyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets exacting standards for research and industrial use. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	118°C - 122°C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.