Description

1-(5-Phospho-β-D-Arabinofuranosyl)-5-Fluorouracil is a fluorinated nucleoside analogue, specifically a 5-fluorouracil derivative with an arabinofuranosyl phosphate moiety. This molecular structure is critical for its role as a key intermediate in the synthesis of advanced pharmaceutical compounds, particularly antimetabolite chemotherapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development and production of novel oncology drugs and antiviral therapies.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of next-generation antimetabolite chemotherapeutic drugs.
• Oncology Research: Used in biochemical and pharmacological research to study mechanisms of action for fluoropyrimidine-based cancer treatments.
• Antiviral Drug Development: Serves as a precursor in the research and development of nucleoside analogue antiviral agents.
• Biochemical Studies: Employed as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism and DNA/RNA synthesis.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.
• Process Chemistry: Integral to scale-up and optimization processes in active pharmaceutical ingredient (API) manufacturing.

Basic Information

Product Name	1-(5-Phospho-β-D-Arabinofuranosyl)-5-Fluorouracil
CAS No.	17124-23-1
Molecular Formula	C9H12FN2O9P
Molecular Weight	366.17 g/mol
Synonyms	5-Fluorouracil Arabinofuranosyl Phosphate; 5-FU Arabinofuranosyl Phosphate; 1-(5-Phosphono-β-D-arabinofuranosyl)-5-fluorouracil; β-D-Arabinofuranosyl 5-fluorouracil 5'-phosphate; 5-Fluorouridine 5'-phosphate (arabinose isomer); 5-FUMP (Ara); Ara-FUMP; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 1-(5-Phospho-β-D-Arabinofuranosyl)-5-Fluorouracil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.