Description

3β,12β,14-Trihydroxy-11-Oxo-5β-Bufa-20,22-Dienolide is a specialized bufadienolide compound, a class of cardiac glycosides with significant biological activity. This high-purity intermediate is critical for pharmaceutical research and development, particularly in the study of cardiac function and novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of complex bioactive molecules and the development of new drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex cardiac glycosides and related steroid derivatives for drug discovery.
• Biochemical Research: Used as a reference standard and active compound in studies investigating Na+/K+-ATPase inhibition and cardiac cell signaling pathways.
• Preclinical Development: Employed in the development and testing of potential therapeutic agents targeting heart failure and other cardiovascular conditions.
• Natural Product Chemistry: Acts as a purified standard for the analysis and characterization of bufadienolides found in traditional medicinal sources.
• Academic Research: Utilized in university and institutional labs for pharmacological and toxicological studies of steroid-like compounds.

Basic Information

Product Name	3β,12β,14-Trihydroxy-11-Oxo-5β-Bufa-20,22-Dienolide
CAS No.	17008-65-0
Molecular Formula	C₂₄H₃₂O₆
Molecular Weight	416.51 g/mol
Synonyms	3β,12β,14-Trihydroxy-11-oxo-5β-bufa-20,22-dienolide; 11-Oxobufalin; 11-Oxobufalin-3,12,14-triol; Bufadienolide A; 3β,12β,14-Trihydroxy-11-oxobufa-20,22-dienolide; 11-Oxo-3β,12β,14-trihydroxybufa-20,22-dienolide
EINECS	Contact for details

Quality Control

Our 3β,12β,14-Trihydroxy-11-Oxo-5β-Bufa-20,22-Dienolide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and related substance profiles.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. Keep the container in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.