Description

Bucladesine Sodium is a cell-permeable, stable analog of cyclic adenosine monophosphate (cAMP) used extensively in biochemical and pharmacological research. This compound is valued for its ability to mimic the intracellular effects of cAMP, making it a critical tool for studying signal transduction pathways and cellular regulation. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors for drug discovery, cell biology studies, and as a reference standard.

Application

• Biochemical Research: As a cell-permeable cAMP analog to study intracellular signaling cascades, protein kinase A (PKA) activation, and gene expression regulation.
• Pharmaceutical R&D: Used in drug discovery programs targeting cardiovascular diseases, neurological disorders, and metabolic conditions where cAMP pathways are implicated.
• Cell Culture & Physiology: Employed to investigate the role of cAMP in cell differentiation, proliferation, and apoptosis in various cell lines.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Enzyme Studies: Utilized as a substrate or modulator in assays for phosphodiesterases and other enzymes involved in nucleotide metabolism.

Basic Information

Product Name	Bucladesine Sodium
CAS No.	16980-89-5
Molecular Formula	C18H23N5NaO8P
Molecular Weight	491.37 g/mol
Synonyms	Dibutyryl Cyclic AMP Sodium Salt; Dibutyryl-cAMP Sodium Salt; N6,2'-O-Dibutyryladenosine 3',5'-cyclic monophosphate sodium salt; Bucladesine; dbcAMP Sodium Salt; DCMP Sodium Salt; Bt2cAMP Na
EINECS	241-045-7

Quality Control

Our Bucladesine Sodium is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and results. The product is suitable for research and development use under current Good Manufacturing Practice (cGMP) guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Meets ICH guidelines
pH (1% Solution)	6.0 - 8.0
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.