Description

(2R,4R,5R)-2-(Hydroxymethyl)-5-(5-Methylsulfanyl-2,4,9-Triazabicyclo[4.3.0]Nona-2,4,7,10-Tetraen-9-Yl)Oxolane-3,4-Diol is a high-purity, complex nucleoside analog with significant pharmaceutical research value. This compound serves as a critical advanced intermediate or reference standard in the development of novel antiviral and anticancer therapeutics. It is primarily sought by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) for use in process development and analytical method validation.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex nucleoside-based antiviral or anticancer drug candidates.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to nucleoside metabolism and nucleic acid synthesis pathways.
• Reference Standard: Serves as a high-purity certified reference material (CRM) for quality control and analytical method development in API manufacturing.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of specialty active pharmaceutical ingredients (APIs).
• Antiviral Drug Development: Investigated for its potential activity and mechanism in targeting viral polymerases or integrases.
• Oncology Research: Explored for its cytotoxic or cytostatic properties in cancer cell line studies and preclinical models.

Basic Information

Product Name	(2R,4R,5R)-2-(Hydroxymethyl)-5-(5-Methylsulfanyl-2,4,9-Triazabicyclo[4.3.0]Nona-2,4,7,10-Tetraen-9-Yl)Oxolane-3,4-Diol
CAS No.	16754-86-2
Molecular Formula	C12H14N4O4S
Molecular Weight	310.33 g/mol
Synonyms	5-Methylthio-7-deazaguanosine; 5-Methylthio-7-deaza-guanosine; 4-Amino-5-methylsulfanyl-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-pyrrolo[2,3-d]pyrimidine; 5-Methylthio-tubercidin; 5-Methylthio-7-deazaguanine riboside; 4-Amino-5-(methylthio)-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine
EINECS	Contact for details

Quality Control

Our production of (2R,4R,5R)-2-(Hydroxymethyl)-5-(5-Methylsulfanyl-2,4,9-Triazabicyclo[4.3.0]Nona-2,4,7,10-Tetraen-9-Yl)Oxolane-3,4-Diol adheres to stringent quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC purity analysis, chiral purity verification, and structural confirmation to ensure identity and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.