Description

6-Chloro-7-Deaza-9-(2',3',5'-Tri-o-Acetyl-β-D-Ribofuranosyl)Purine is a key nucleoside analog intermediate with a protected ribose moiety, designed for advanced synthetic chemistry. This compound matters for its role as a versatile building block in the synthesis of modified nucleosides and nucleotides, enabling the development of novel therapeutic agents and research tools. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on antiviral drug discovery, oligonucleotide synthesis, and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used as a modified building block for incorporating 7-deazapurine bases into DNA/RNA strands for research and therapeutic applications.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Biochemical Probe Development: Enables the creation of labeled or modified nucleotides for studying enzyme mechanisms and nucleic acid interactions.
• Antiviral Agent Development: Particularly relevant for research targeting viral polymerases, where modified nucleosides can act as chain terminators.
• Academic & Contract Research: A valuable reagent for universities and CROs conducting fundamental research in nucleic acid chemistry and biochemistry.

Basic Information

Product Name	6-Chloro-7-Deaza-9-(2',3',5'-Tri-o-Acetyl-β-D-Ribofuranosyl)Purine
CAS No.	16754-79-3
Molecular Formula	C18H18ClN5O7
Molecular Weight	451.82 g/mol
Synonyms	6-Chloro-7-deaza-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine; 6-Chloro-7-deazapurine riboside triacetate; 6-Chloro-7-iodo-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine (common precursor); 9-(2,3,5-Tri-O-acetyl-β-D-ribofuranosyl)-6-chloro-7H-pyrrolo[2,3-d]pyrimidine; 6-Chloro-7-deazaadenosine triacetate; 6-Cl-7-deaza-9-(triacetylribosyl)purine; Nucleoside Intermediate 16754-79-3
EINECS	Contact for details

Quality Control

Our 6-Chloro-7-Deaza-9-(2',3',5'-Tri-o-Acetyl-β-D-Ribofuranosyl)Purine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and handled under appropriate conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.