Description

7-Epi-Clindamycin CAS NO 16684-06-3 is a key semi-synthetic derivative of the lincosamide antibiotic clindamycin. This compound is of significant interest in pharmaceutical research and development, primarily as a critical intermediate or reference standard. It is essential for organizations engaged in the synthesis of novel antibiotics, metabolic studies, and analytical method development for quality control in pharmaceutical manufacturing.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for the identification, assay, and impurity profiling of clindamycin and related pharmaceutical products.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a crucial building block in the synthetic pathways for advanced clindamycin derivatives and novel lincosamide antibiotics.
• Metabolic and Pharmacokinetic Research: Employed in studies investigating the metabolism, distribution, and stability of clindamycin within biological systems.
• Analytical Method Development: Utilized for calibrating equipment and validating analytical methods such as HPLC, LC-MS, and NMR in quality control laboratories.
• Impurity Standard: Acts as a specified impurity standard to monitor and control the quality of clindamycin hydrochloride and other related drug substances according to pharmacopeial guidelines (e.g., USP, EP).
• Biochemical Research: Used in microbiological and biochemical research to study structure-activity relationships and mechanisms of action against susceptible organisms.

Basic Information

Product Name	7-Epi-Clindamycin
CAS No.	16684-06-3
Molecular Formula	C18H33ClN2O5S
Molecular Weight	424.98 g/mol
Synonyms	(2S,4R)-N-[(1S,2S)-2-Chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)oxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide; 7(S)-Clindamycin; Clindamycin, 7-epimer; 7-Epimer of Clindamycin; 7-Epi-clindamycin; U-28508; Antibiotic U 28508
EINECS	Contact for details

Quality Control

Our 7-Epi-Clindamycin is manufactured and tested under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assay by HPLC, and control of related substances and residual solvents in compliance with ICH guidelines. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and consistent quality for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.