Description

8,2'β-Epithio-2'-Deoxyadenosine is a chemically modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a critical building block and a valuable tool for investigating nucleic acid chemistry and designing novel therapeutic agents. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of antiviral drugs, anticancer therapies, and advanced molecular probes. Its unique epithio modification offers a pathway to explore novel mechanisms of action and biochemical interactions.

Application

• Pharmaceutical Intermediate: A key synthon in the research and synthesis of novel nucleoside-based antiviral and anticancer agents.
• Biochemical Research: Used as a specialized substrate or inhibitor in enzymatic studies related to DNA/RNA metabolism and repair.
• Probe Development: Acts as a precursor for creating labeled or modified nucleotides used in diagnostic assays and molecular biology techniques.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of therapeutic candidates.
• Academic Research: Utilized in universities and research institutes for fundamental studies in organic synthesis and bioorganic chemistry.

Basic Information

Item	Detail
Product Name	8,2'β-Epithio-2'-Deoxyadenosine
CAS No.	16667-76-8
Molecular Formula	C10H11N5O3S
Molecular Weight	281.29 g/mol
Synonyms	8,2'-Epithio-2'-deoxyadenosine; 2'-Deoxy-8,2'-epithioadenosine; 9-(2-Deoxy-2,8-epithio-β-D-erythro-pentofuranosyl)adenine; 8,2'-Anhydro-8-mercapto-2'-deoxyadenosine; 8,2'-S-Cyclo-2'-deoxyadenosine; 8,2'-Thioanhydro-2'-deoxyadenosine; 2'-Deoxy-8,2'-thioanhydroadenosine
EINECS	Contact for details

Quality Control

Our 8,2'β-Epithio-2'-Deoxyadenosine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods (NMR, MS) for structural confirmation, to ensure it meets the exacting standards required for research and development. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.