Description

6-Thioguanosine 5'-Diphosphate is a modified nucleotide analog of guanosine diphosphate, where the oxygen atom at the 6-position is replaced by sulfur. This structural modification is critical for its role as a potent inhibitor of specific GTP-binding proteins and enzymes involved in nucleotide metabolism. It is an essential biochemical tool for researchers in enzymology, signal transduction, and molecular pharmacology, providing a mechanism to study and modulate purinergic signaling pathways. The compound is supplied with high purity to ensure reliable and reproducible experimental results.

Application

• Enzymology Research: Used as a substrate analog or competitive inhibitor to study the kinetics and mechanisms of GTPases, kinases, and other nucleotide-dependent enzymes.
• Signal Transduction Studies: Employed to investigate and manipulate G-protein coupled receptor (GPCR) pathways and other cellular signaling cascades that utilize GTP.
• Molecular Pharmacology: Serves as a key reagent in high-throughput screening assays to identify novel therapeutic agents targeting purine nucleotide-binding sites.
• Biochemical Synthesis: Acts as a building block or precursor in the enzymatic synthesis of modified oligonucleotides for specialized research applications.
• Cell Biology: Utilized in studies of cellular processes such as protein synthesis, cytoskeletal dynamics, and vesicular transport where GTP hydrolysis provides energy.

Basic Information

Product Name	6-Thioguanosine 5'-Diphosphate
CAS No.	16541-19-8
Molecular Formula	C10H16N5O13P3S
Molecular Weight	555.23 g/mol
Synonyms	6-Thio-GDP; 6-Thioguanosine diphosphate; 6-S-GDP; GDP-6-thio; Guanosine 5'-[trihydrogen diphosphate], 6-thio-; 6-Mercaptoguanosine 5'-diphosphate; 6-SH-GDP
EINECS	Contact for details

Quality Control

Our 6-Thioguanosine 5'-Diphosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom purity grades and analytical packages are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and storage under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in water or buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.