Description

Difluoro(Phenylsulfanyl)Acetyl Chloride is a versatile and highly reactive organosulfur building block, primarily used as a key intermediate in advanced organic synthesis. Its unique structure, featuring both a reactive acid chloride group and a phenylthioether moiety, makes it invaluable for introducing difluoroacetyl and sulfur-containing functional groups into target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in the development of protease inhibitors and other bioactive molecules containing difluoromethyl and thioether motifs.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the difluoroacetyl group can enhance metabolic stability and bioavailability.
• Material Science Research: Serves as a precursor for functionalized monomers or ligands in the development of specialized polymers and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes (ABPs) for studying enzyme function and mechanism.
• Cross-Coupling Reactions: Acts as an electrophilic coupling partner in palladium-catalyzed reactions for constructing complex carbon-sulfur bonds.
• Fluorine Chemistry: A valuable reagent for introducing the difluoromethylene (CF2) unit into organic molecules, a common strategy in modern medicinal chemistry to modulate physicochemical properties.

Basic Information

Product Name	Difluoro(Phenylsulfanyl)Acetyl Chloride
CAS No.	16503-77-8
Molecular Formula	C8H5ClF2OS
Molecular Weight	222.64 g/mol
Synonyms	2,2-Difluoro-2-(phenylthio)acetyl Chloride; α,α-Difluoro-α-(phenylthio)acetyl Chloride; (Phenylthio)difluoroacetyl Chloride; Difluoro(phenylthio)acetyl Chloride; Phenylsulfanyldifluoroacetyl Chloride; 16503-77-8; (Phenylsulfanyl)difluoroacetyl chloride
EINECS	Contact for details

Quality Control

Our Difluoro(Phenylsulfanyl)Acetyl Chloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including NMR (¹H, ¹³C, ¹⁹F), HPLC, and GC analysis, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical parameters. Our quality commitment ensures the material meets the stringent requirements for research and process development applications.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from heat, open flames, and incompatible materials such as bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.