Description

2-Azido-2-Phenylacetyl Chloride is a specialized, highly reactive organic acid chloride derivative. This compound serves as a critical building block in advanced organic synthesis, particularly for the introduction of the azido functional group under mild conditions. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional polymers. Its unique structure enables efficient click chemistry and peptide coupling reactions.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel β-lactam antibiotics and other bioactive molecules.
• Peptide Chemistry: Used for the incorporation of azido-modified amino acids and as a coupling agent in peptide synthesis.
• Click Chemistry Reagent: Essential for Huisgen 1,3-dipolar cycloaddition reactions to create triazole linkages in bioconjugation and polymer chemistry.
• Agrochemical Synthesis: Building block for creating new herbicides and fungicides with unique modes of action.
• Polymer Functionalization: Enables the introduction of azide groups onto polymer backbones for subsequent cross-linking or labeling.
• Material Science Research: Used in the development of advanced materials, including surface modifiers and photoactive compounds.
• Proteomics and Bioconjugation: Facilitates the labeling and study of proteins and other biomolecules.

Basic Information

Product Name	2-Azido-2-Phenylacetyl Chloride
CAS No.	16461-71-5
Molecular Formula	C8H6ClN3O
Molecular Weight	195.61 g/mol
Synonyms	α-Azido-α-phenylacetyl chloride; 2-Azido-2-phenylacetyl chloride; Azidophenylacetyl chloride; (Azidophenyl)acetyl chloride; Phenyl(azido)acetyl chloride; NSC 163045; α-Phenyl-α-azidoacetyl chloride
EINECS	Contact for details

Quality Control

Our 2-Azido-2-Phenylacetyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of research and development as well as scale-up production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at temperatures between 2°C and 8°C (refrigerated) or as specified on the label. This compound is highly volatile, easily oxidized, and reacts with strong acids/organic solvents; it must be stored under an inert atmosphere (e.g., nitrogen or argon) and kept away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.