Description

Formycin Triphosphate is a nucleotide analog triphosphate derivative of the antibiotic formycin, serving as a critical biochemical reagent for enzymatic studies. Its primary value lies in its ability to act as an alternative substrate or inhibitor for various ATP-dependent enzymes, including polymerases and kinases, facilitating research into nucleic acid metabolism and enzyme mechanisms. This compound is essential for researchers and manufacturers in the fields of molecular biology, enzymology, and pharmaceutical development, where precise biochemical probes are required.

Application

• Enzymology Research: Used as a substrate analog to study the kinetics and mechanisms of ATP-utilizing enzymes such as RNA/DNA polymerases and protein kinases.
• Nucleic Acid Synthesis Inhibition: Acts as a chain terminator or inhibitor in in vitro transcription and replication assays to probe polymerase fidelity and function.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) platforms to identify novel enzyme inhibitors for drug discovery programs.
• Antiviral & Anticancer Research: Investigated for its potential to interfere with viral replication or cellular signaling pathways due to its structural similarity to natural nucleotides.
• Metabolic Pathway Analysis: Serves as a tool to trace and understand nucleotide salvage and de novo synthesis pathways in cellular models.
• Diagnostic Reagent Manufacturing: Incorporated into specialized kits for research and diagnostic applications requiring nucleotide analogs.

Basic Information

Product Name	Formycin Triphosphate
CAS No.	16409-13-5
Molecular Formula	C11H15N4O13P3
Molecular Weight	528.16 g/mol
Synonyms	Formycin 5'-Triphosphate; 7-Amino-3-(β-D-ribofuranosyl)pyrazolo[4,3-d]pyrimidine 5'-triphosphate; FTP; 1,4,5,6-Tetrahydro-8-(β-D-ribofuranosyl)-1,5-dihydro-4,6-dioxopyrazolo[3,4-d]pyrimidine 5'-triphosphate; NSC 154132; Formycin TP; Formycin-5'-triphosphate
EINECS	Contact for details

Quality Control

Our Formycin Triphosphate is produced under stringent quality management protocols to ensure batch-to-batch consistency and high purity for critical research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 standards, and our quality systems are designed to support research requiring regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term stability, avoid repeated freeze-thaw cycles and store under inert atmosphere when possible.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, slightly soluble in methanol
Biological Activity	Tested in standard enzymatic assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.