Description

3α,5α-Tetrahydronorethisterone is a synthetic steroid derivative, specifically a reduced metabolite of norethisterone. This compound is of significant interest in pharmaceutical research and development due to its role as a key intermediate or reference standard in the synthesis and analysis of steroidal drugs. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of hormonal therapies, analytical method validation, and quality control processes for active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of more complex steroidal active pharmaceutical ingredients (APIs).
• Reference Standard: Used as a high-purity analytical standard in HPLC, GC, and other chromatographic methods for quality control and method validation.
• Biochemical Research: Employed in metabolic pathway studies and pharmacological research related to progestogens and their derivatives.
• API Impurity Profiling: Essential for identifying and quantifying related substances and degradation products in final drug substance specifications.
• Academic & Contract Research: Utilized in university laboratories and CROs (Contract Research Organizations) for investigative studies and client projects.

Basic Information

Product Name	3α,5α-Tetrahydronorethisterone
CAS No.	16392-60-2
Molecular Formula	C₂₀H₃₀O₂
Molecular Weight	302.45 g/mol
Synonyms	19-Nor-17α-pregn-4-en-20-yn-3-one, 17β-hydroxy-5α-tetrahydro-; 5α-Tetrahydro-19-nor-17α-pregn-4-en-20-yn-3-one, 17β-hydroxy-; 3α,5α-Tetrahydro-19-nor-17α-ethynyltestosterone; 3α,5α-Tetrahydro-19-nor-17α-ethynyl-4-androsten-17β-ol-3-one; 17β-Hydroxy-5α-estr-4-en-3-one; 3α,5α-Tetrahydro-19-nor-17α-ethynyltestosterone; 19-Nor-17α-pregn-4-en-20-yn-3-one, 17β-hydroxy-5α-tetrahydro-
EINECS	Contact for details

Quality Control

Our 3α,5α-Tetrahydronorethisterone is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling, to ensure it meets the stringent requirements for research and pharmaceutical use. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.