Description

2'-Deoxyadenosine Monohydrate is a nucleoside derivative and a fundamental building block of DNA. This high-purity compound is critical for life science research, pharmaceutical development, and diagnostic applications. It is primarily utilized by biotech companies, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) and oligonucleotides.

Application

• Oligonucleotide Synthesis: A key phosphoramidite monomer for the solid-phase synthesis of DNA strands and probes.
• Pharmaceutical Intermediates: Serves as a crucial starting material or intermediate in the synthesis of nucleoside-based antiviral and anticancer drugs.
• Biochemical Research: Used as a substrate for enzymes like kinases and polymerases in metabolic pathway studies and enzymatic assays.
• Cell Culture & Media: Incorporated into specialized cell culture media to support the growth of fastidious cell lines.
• Diagnostic Reagents: A component in the formulation of reagents for molecular diagnostics, including PCR and sequencing.
• Standards & Calibrants: Employed as a high-purity reference standard in analytical chemistry for quantification and method validation.

Basic Information

Product Name	2'-Deoxyadenosine Monohydrate
CAS No.	16373-93-6
Molecular Formula	C10H13N5O3 · H2O
Molecular Weight	269.25 g/mol (Anhydrous basis: 251.24)
Synonyms	2'-Deoxyadenosine hydrate; 9-(2-Deoxy-β-D-erythro-pentofuranosyl)adenine monohydrate; dA Monohydrate; Deoxyadenosine hydrate; Adenine deoxyriboside monohydrate; 2'-dA·H2O
EINECS	Contact for details

Quality Control

Our 2'-Deoxyadenosine Monohydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and stringent tests for residual solvents and moisture content. Certificates of Analysis (COA) with full traceability are provided to ensure compliance with research and cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	5.0% - 8.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.