Description

4-Pregnen-6-Beta, 17,21-Triol-3,11,20-Trione is a high-purity steroid derivative, also known as 6β-Hydroxycortisol, which serves as a critical intermediate and reference standard in advanced pharmaceutical research and development. Its value lies in its role as a key metabolite and synthetic precursor for investigating cortisol metabolism and developing novel corticosteroid-based therapeutics. This compound is essential for pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions focused on endocrinology, anti-inflammatory drug discovery, and analytical method development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel corticosteroid drugs and their metabolites.
• Reference Standard: Used for the calibration of analytical equipment (HPLC, LC-MS) and for qualitative/quantitative analysis in bioanalytical studies.
• Metabolite Research: Critical for studying the metabolic pathways, pharmacokinetics, and biological activity of cortisol and related steroids.
• Biochemical Research: Employed in enzymatic studies and receptor-binding assays to understand steroid hormone action and regulation.
• Quality Control: Serves as an impurity marker or system suitability standard in the quality control of bulk corticosteroid APIs.

Basic Information

Product Name	4-Pregnen-6-Beta, 17,21-Triol-3,11,20-Trione
CAS No.	16355-28-5
Molecular Formula	C21H28O6
Molecular Weight	376.45 g/mol
Synonyms	6β-Hydroxycortisol; 6β,17α,21-Trihydroxy-4-pregnene-3,11,20-trione; 6β-Hydroxyhydrocortisone; 11β,17α,21-Trihydroxy-6β-pregn-4-ene-3,20-dione; Cortisol, 6β-hydroxy-; NSC 113935; U 6013
EINECS	Contact for details

Quality Control

Our 4-Pregnen-6-Beta, 17,21-Triol-3,11,20-Trione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are provided to guarantee traceability, consistency, and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is light-sensitive and easily oxidized; for long-term storage, consider under an inert atmosphere to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.