Description

14-Hydroxyestradiol is a hydroxylated metabolite of the primary female sex hormone, estradiol. This compound is of significant interest in biochemical and pharmaceutical research due to its role in estrogen metabolism and its potential biological activity. It serves as a critical reference standard and intermediate for researchers and manufacturers in the life sciences sector. Key applications include use as a biomarker in clinical studies and as a precursor in the synthesis of more complex steroid derivatives.

Application

• Pharmaceutical Reference Standard: Used for the calibration of analytical instruments and the validation of methods in drug development and quality control laboratories.
• Biochemical Research: Employed in metabolic pathway studies to understand the hydroxylation and inactivation mechanisms of endogenous estrogens.
• Clinical Diagnostics: Acts as a key analyte or calibrant in the development of immunoassays and LC-MS/MS methods for hormone level monitoring.
• Academic Research: Serves as a reagent in university and institutional labs for endocrinology and steroid chemistry investigations.
• API Intermediate: Utilized as a building block in the synthetic pathway for novel steroidal drug candidates and therapeutic agents.

Basic Information

Item	Details
Product Name	14-Hydroxyestradiol
CAS No.	16288-09-8
Molecular Formula	C18H24O3
Molecular Weight	288.38 g/mol
Synonyms	14α-Hydroxyestradiol; Estra-1,3,5(10)-triene-3,14α,17β-triol; 14-Hydroxy-E2; 14α-Hydroxy-17β-estradiol; 3,14α,17β-Trihydroxyestra-1,3,5(10)-triene
EINECS	Contact for details

Quality Control

Our 14-Hydroxyestradiol is produced and handled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity assessment by HPLC, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be stored away from direct light exposure.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.