Description

4-Thiazolecarbonyl Chloride, 2-Chloro- (8Ci,9Ci) is a highly reactive and versatile heterocyclic acid chloride building block, essential for advanced organic synthesis. Its core value lies in enabling the efficient introduction of the 2-chlorothiazole-4-carbonyl moiety, a key structural motif in the development of active pharmaceutical ingredients and agrochemicals. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in antiviral, antibacterial, and kinase inhibitor research.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the thiazole ring confers specific bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalytic systems and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functional polymers and organic electronic materials with unique properties.
• Peptide Mimetics: Facilitates the incorporation of thiazole-based scaffolds into peptide chains to enhance stability and biological activity.
• Custom Synthesis and Contract Manufacturing: A critical reagent for fine chemical manufacturers offering bespoke synthesis services to global clients.

Basic Information

Product Name	4-Thiazolecarbonyl Chloride, 2-Chloro- (8Ci,9Ci)
CAS No.	16099-04-0
Molecular Formula	C4HCl2NOS
Molecular Weight	182.02 g/mol
Synonyms	2-Chloro-1,3-thiazole-4-carbonyl chloride; 2-Chlorothiazole-4-carbonyl chloride; 2-Chloro-4-thiazolecarbonyl chloride; 2-Chloro-4-thiazolylcarbonyl chloride; 2-Chloro-1,3-thiazole-4-carboxylic acid chloride; 2-Chlorothiazole-4-carboxylic acid chloride; 4-Thiazolecarbonyl chloride, 2-chloro-; 2-Chloro-4-carboxythiazoyl chloride
EINECS	Contact for details

Quality Control

Our 4-Thiazolecarbonyl Chloride, 2-Chloro- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.