Description

1-(2'-Deoxy-β-Threopentofuranosyl)Thymine is a specialized nucleoside derivative, a key building block in oligonucleotide synthesis and biochemical research. This compound is crucial for the development and study of modified DNA and RNA sequences, offering researchers precise control over nucleic acid structure and function. It is primarily utilized by pharmaceutical R&D teams, diagnostic developers, and academic laboratories focused on antisense technology, molecular probes, and therapeutic oligonucleotides.

Application

• Oligonucleotide Synthesis: Serves as a critical phosphoramidite precursor for the solid-phase synthesis of modified DNA strands.
• Antisense & siRNA Research: Used in the development of therapeutic oligonucleotides designed to target specific mRNA sequences.
• Molecular Diagnostics: Incorporated into probes and primers to enhance specificity and stability in diagnostic assays.
• Biochemical Studies: Acts as a substrate or inhibitor in enzymatic studies involving DNA polymerases and nucleoside metabolizing enzymes.
• Medicinal Chemistry: Provides a scaffold for the development of novel nucleoside analog pharmaceuticals.
• Academic Research: Fundamental tool for investigating DNA structure, replication, and repair mechanisms.

Basic Information

Product Name	1-(2'-Deoxy-β-Threopentofuranosyl)Thymine
CAS No.	16053-52-4
Molecular Formula	C10H14N2O5
Molecular Weight	242.23 g/mol
Synonyms	2'-Deoxy-β-threo-thymidine; 2'-Deoxythreothymidine; 1-(2-Deoxy-β-threo-pentofuranosyl)thymine; β-Threo-thymidine 2'-deoxy; Thymidine, 2'-deoxy-β-threo-; d-Threo-thymidine; 16053-52-4 (CAS)
EINECS	Contact for details

Quality Control

Our 1-(2'-Deoxy-β-Threopentofuranosyl)Thymine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality commitment aligns with the standards expected for advanced pharmaceutical intermediates and high-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.